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Updated: Oct 15, 2026

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
Published on: July 16, 2017
MONDE·T: A database and interactive webserver for non-standard amino acids and peptide components in the PDB
Alex Waldherr1, Gesa L Freimann1, Andrei N Lupas1
1Department for Protein Evolution, Max Planck Institute for Biology, Tübingen, Germany.
Abstract:
Non-standard amino acids (ncAAs) together with synthetic additions (like caps and linkers) are of wide interest for protein design and pharmaceutical optimization, as they can improve physicochemical properties and possibly reshape protein structure. Their inclusion in experimental structures has not been explored systematically. It remains elusive which components are those most impactful for protein design. We therefore collected all non-standard components present in the Protein Data Bank (PDB) into MONDE·T: A database of 1,210 unique ncAAs and 724 other synthetic components present in 23,149 PDB structures with a corresponding webserver. Analyses can focus on a single component or a single structure, illustrated here by example applications. MONDE·T allows for download of the data, visualization of a structure, identification of unusual backbone angles, and comparison of chemical similarities. The webserver is hosted at the Max Planck Institute Tübingen, accessible online via https://mondet.tuebingen.mpg.de/. MONDE·T is freely available under the Creative Commons 4.0 License.
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