Related Experiment Video
Updated: Oct 15, 2026
A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis
Published on: November 30, 2021
Social determinants of necrotizing enterocolitis-associated mortality in very low birth weight infants: a population
Keliy Fordham1,2, Leslie A Parker1, Yingwei Yao1
1College of Nursing, University of Florida, Gainesville, FL, USA.
Objectives:
Necrotizing enterocolitis (NEC) remains a leading cause of morbidity and mortality among very low birth weight (VLBW) infants. This study examined associations between maternal social determinants of health (SDoH) and NEC-related infant mortality among VLBW infants.
Methods:
This retrospective cross-sectional study used Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiological Research (CDC WONDER) linked birth and death records from 2017 to 2023. Associations between maternal SDoH and NEC-related mortality were assessed using logistic regression.
Results:
Among 271,411 VLBW births, 1,725 NEC-associated deaths occurred, yielding a mortality rate of 6.36 per 1,000 live VLBW births. Younger maternal age, unmarried status, Medicaid insurance, and residence in the southern United States were associated with increased mortality risk. Infants of American Indian or Alaska Native (AIAN) mothers also had higher odds of NEC-related death, whereas infants of mothers aged 30-34 years or with a bachelor's degree or higher had reduced risk.
Conclusions:
Maternal socioeconomic disparities are associated with NEC-associated mortality in VLBW infants, underscoring the need to address these disparities to improve outcomes.
More Related Videos
09:36Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers
Published on: July 28, 2022
06:51Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome
Published on: July 28, 2023