Science Is a Lot of Fun: How Professor Jes Olesen Made Discoveries in Migraine
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Updated: Oct 15, 2026

Investigating Migraine-Like Behavior Using Light Aversion in Mice
Published on: August 11, 2021
1Department of Neurology, Ural State Medical University, Yekaterinburg, Russia.
Abstract:
The human provocation model, cortical spreading depression during the aura and the identification of CGRP all came from one investigator following the same method for 60 years. Marking the 85th birthday of Professor Jes Olesen, Honorary Member of the EAN and founder of the European Journal of Neurology, this interview describes how each discovery was actually obtained. Migraine, once a disorder in which nothing could be measured, now has an objectively documented aura, an established molecular physiology, criteria used worldwide and drugs designed against a target these experiments identified.
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