Related Experiment Video
Updated: Oct 15, 2026

Murine Renal Transplantation Procedure
Published on: July 10, 2009
Race-Neutral Glomerular Filtration Rate Projected to Increase Kidney Transplantation for Black Patients: Initial
Arianna Cabrales1, Kirsten Fernando1, Tim Craven1
1Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Abstract:
The 2023 organ procurement and transplantation network (OPTN) policy "Modify waiting time for candidates affected by race-inclusive eGFR calculations" for kidney transplantation (KT) was analyzed at our kidney transplant center over a 15-month period following its implementation. A total of 372 adult Black patients active on our KT waiting list were identified, of whom 104 (28%) qualified for waiting-time modification (WTM). The WTM group gained a median total waiting time of 2.4 years, with 36 (35%) receiving KTs compared to 107 (42%) in the no wait-time modification (NWTM) group. Pre-listing time, older age, female gender, and A or B blood type was found to increase likelihood of KT in both groups. Despite lower actual transplant rates during the study period, the WTM group is projected to gain a 25% annual probability of transplant for each additional year of qualifying time. Therefore, while the decision to grant WTM has generated some controversy, short-term outcomes at our center suggest that the OPTN policy change has the potential to improve transplant access among Black patients without necessarily disadvantaging those Black patients who do not benefit from WTM. Longer follow-up is required to determine the intended and unintended effects of the race-neutral GFR (rnGFR) and WTM policy changes.
Related Concept Videos
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
Kidney Transplant I: Introduction
Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate
Renal Drug Excretion: Glomerular Filtration
Drugs gain access to the kidney via the renal artery, which progressively branches off into afferent arterioles.
Kidney Transplant III: Nursing Management
Factors Affecting Renal Clearance: Renal Impairment
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
