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Published on: March 3, 2023
Treatment Failure After Laparoscopic Radiofrequency Ablation Compared With Myomectomy
Katherine S Brito1, Michael Schembri, Ram Parvataneni
1Department of Obstetrics, Gynecology and Reproductive Sciences and the Department of Medicine, University of California, San Francisco, School of Medicine, San Francisco, the Department of Obstetrics and Gynecology, University of California, Los Angeles, Los Angeles, the Department of Obstetrics and Gynecology, University of California, San Diego, San Diego, the Department of Obstetrics and Gynecology, University of California, Irvine, Irvine, the Department of Obstetrics and Gynecology, University of California, Davis, School of Medicine, Davis, and the University of California Fibroid Network, San Francisco, Los Angeles, Davis, Irvine, and San Diego, California; the Department of Obstetrics and Gynecology, Duke University, Durham, North Carolina; the Fibroid Pelvic and Wellness Center of Georgia, Peachtree Corners, Georgia; the Gynecological Institute of Chicago, Chicago, Illinois; Tassone Advanced Gynecology, Round Rock, Texas; and the Department of Obstetrics and Gynecology, Cornell University School of Medicine, New York, New York.
Objective:
To compare treatment failure and factors associated with failure between laparoscopic radiofrequency ablation (RFA) of leiomyomata and laparoscopic myomectomy.
Methods:
We analyzed data from the multicenter prospective ULTRA (Uterine Leiomyoma Treatment with Radiofrequency Ablation) study, which investigated laparoscopic RFA and laparoscopic myomectomy for symptomatic uterine leiomyomata. Our primary outcome was receipt of any subsequent procedure (surgical failure) for leiomyomata within 2 years of the procedure. Our secondary outcome was composite failure (surgical failure or any self-reported failure, eg, continued leiomyomata symptoms affecting quality of life) within 2 years of the procedure. Odds ratios (ORs) were generated from multivariable logit models adjusting for a priori selected covariates.
Results:
We identified significant baseline differences between our groups. The RFA group (n=231) was older and had higher body mass index (BMI), gravidity, and parity than the myomectomy group (n=110). In the RFA group, 15.2% experienced surgical failure compared with 3.8% in the myomectomy group (adjusted odds ratio [aOR] 4.17; 95% CI, 1.39-12.50), and 46.4% experienced composite failure in the RFA group compared with 25.5% in the myomectomy group (aOR 3.18; 95% CI, 1.80-5.60). Submucosal leiomyomata were associated with failure in the RFA group (OR 2.76; 95% CI, 1.21-6.28); there was a nonsignificant trend toward failure in the myomectomy group (OR 3.00; 95% CI, 0.99-9.05). Lateral leiomyomata were associated with higher odds of RFA failure (OR 2.49; 95% CI, 1.32-4.69), but no leiomyoma position was associated with myomectomy failure.
Conclusion:
Laparoscopic RFA of leiomyomata is associated with higher odds of surgical and composite failure compared with laparoscopic myomectomy at 2 years, even after adjusting for baseline differences between groups.
Clinical Trial Registration:
ClinicalTrials.gov, NCT02100904.
