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Updated: Oct 15, 2026

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
Published on: January 7, 2014
Perspectives on ionizing radiation and Parkinson's disease
Kathleen B Miller1,2, Nilufar Ali3, Mandi Beavers4
1Department of Health and Exercise Science, University of St. Thomas, Saint Paul, MN, USA. mill4945@stthomas.edu.
Abstract:
Emerging evidence from terrestrial cohorts suggests that ionizing radiation (IR) exposure may increase the risk of Parkinson's disease (PD). Understanding the biological mechanisms underlying IR-induced PD is therefore critical for assessing health risks, particularly in the context of long-duration missions to the Moon and Mars. This perspective explores mechanistic pathways that may support causal links between IR and PD and highlights experimental and epidemiological approaches relevant for strengthening causal inference.
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