Single-Molecule Force Spectroscopy: Experiments, Analysis, and Simulations

Ismahene Mesbah1, Fidan Sumbul1, Claire Valotteau1

  • 1Aix-Marseille Univ, INSERM, DyNaMo, Turing Centre for Living Systems, 13009, Marseille, France.

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A covalently bonded heteronuclear diatomic molecule can be modeled as two vibrating masses connected by a spring. The vibrational frequency of the bond can be expressed using an equation derived from Hooke's law, which describes how the force applied to stretch or compress a spring is proportional to the displacement of the spring. In this case, the atoms behave like masses, and the bond acts like a spring.
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