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Multitarget Drug Design for Cardiovascular Disease: Bridging Chemistry and Medicine
Gyuzel Y Mitronova1,2,3, Vladimir N Belov2, Constanze Schmidt3,4
1Translational Neuroinflammation and Automated Microscopy TNM, Fraunhofer-Institute for Translational Medicine and Pharmacology, Göttingen, Germany.
Abstract:
This review provides an overview of recent advances in the development of multitarget drugs (MTDs) for cardiac diseases, with a particular focus on emerging molecular scaffolds and their pharmacological properties. We discuss the fundamental principles of cardiac polypharmacology and multitarget drug design, highlighting key compound classes, such as 1,4-benzothiazepines, 1,4-dihydropyridines (DHPs), and polyphenol derivatives. Particular emphasis is placed on the relationship between the structural features and the pharmacological activity, efficacy, and therapeutic potential of these compounds.
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