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Cardioprotection Is a Delivery Problem: A First-Medical-Contact Framework for Acute Myocardial Infarction
Vibhudutta Awasthi1, Tarun W Dasari2, Kenichi A Tanaka3
1Department of Pharmaceutical Sciences, University of Oklahoma College of Pharmacy, 1110 North Stonewall Avenue, Oklahoma City, Oklahoma 73117, United States.
Abstract:
Dozens of agents that limit reperfusion injury preclinically have failed clinically. These failures are architectural, not biological: the right biology reaches the wrong place, as the wrong molecule, at the wrong time, judged by the wrong end point. We recast each as a design constraint and specify a staged regimen anchored at first medical contact.
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