Related Experiment Video
Updated: Oct 16, 2026

Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
The Evolving Genomic Landscape of Pediatric Papillary Thyroid Cancer
Julio C Ricarte-Filho1, Aime T Franco1,2
1Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, United States.
Abstract:
Thyroid cancer is a rare cancer in the pediatric population, but incidences are rising. Thyroid tumors in children have a unique set of clinical, pathological and molecular features, and compared to adults often present with more invasive and metastatic disease. The genetic and molecular features of pediatric and adult tumors share many similar characteristics, but the prevalence of gene fusions is much higher in pediatric patients where these fusions confer greater risk for invasive and metastatic disease. Here we summarize the molecular features of pediatric papillary thyroid cancers and how these characteristics may help to guide clinical management of patients with the disease.
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