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Updated: Oct 16, 2026

A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products
Published on: September 9, 2016
An alternative route for the total synthesis of gymnothelignan L
Xinyu Liang1, Zhiyu Zhang1, Shuyang Luan1
1State Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, 222 South Tianshui Road, Lanzhou, 730000, China. lihuilin@lzu.edu.cn.
Abstract:
Gymnothelignan L is a representative dibenzocyclooctene-type member of a large class of novel gymnothelignan natural products. We have previously achieved its first total synthesis by developing a bioinspired Friedel-Crafts cyclization approach. Herein, we report a second-generation synthesis to serve as an alternative synthetic route to gymnothelignan L through intramolecular dehydration and Friedel-Crafts cyclization from a linear gymnothelignan precursor with a C9 alcohol and a C6 aldehyde.
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