Study of Krüppel-like Factor 14 rs4731702 Polymorphism in Type 2 Diabetes Mellitus

Krüppel-Like Factor 14 (KLF14) polymorphism has been investigated as a potential genetic risk factor for type 2 diabetes mellitus (T2DM). This study aimed to evaluate the association between KLF14 rs4731702 (C/T) polymorphism and T2DM susceptibility in Egyptians.

A case-control study was conducted on 100 patients with T2DM and 100 healthy controls. Genotyping of KLF14 rs4731702 (C/T) was performed using restriction fragment length polymorphism polymerase chain reaction (RFLP-PCR). Clinical and biochemical parameters were compared among different genotypes.

The CT and TT genotypes were significantly more frequent in diabetic patients (40% and 30%, respectively) than in controls (15% and 20%, respectively) (p<0.001). Subjects carrying CT and TT genotypes showed significantly higher fasting blood glucose, HbA1c, total cholesterol, and triglyceride levels than those carrying the CC genotype.

These findings suggest a possible association between the T allele and metabolic abnormalities associated with T2DM.

KLF14 rs4731702 (C/T) polymorphism is significantly associated with susceptibility to T2DM in the Egyptian population. The increased prevalence of CT and TT genotypes, along with their association with hyperglycemia and dyslipidemia, suggests that the T allele may contribute to metabolic disturbances and disease development. Further large-scale studies are needed to confirm these findings and clarify the underlying mechanisms.