Related Experiment Video
Updated: Oct 16, 2026

Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
Contemporary systemic therapy of medullary thyroid cancer
1Department of Oncology, University of Alberta and Cross Cancer Institute, Edmonton, Alberta, Canada.
Introduction:
Medullary thyroid cancer (MTC) is a less common subtype of thyroid cancer, and it should be managed under the care of expert multidisciplinary teams.
Areas Covered:
Based on the available literature, the role of systemic therapy for MTC has evolved over the past couple of decades in line with the rapid development in our understanding of the biology of this cancer. Despite the initial successes of selective RET inhibitors in achieving good responses and reasonable disease control, resistance eventually develops in most patients.
Expert Opinion:
There is an unmet need to develop newer therapeutic approaches for the management of MTC. This should happen through multicenter, international collaborative efforts given the rarity of this cancer.
Related Concept Videos
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Tumor Immunotherapy
Treatment Resistant Cancers
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Hyperthyroidism I: Introduction
