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Updated: Oct 16, 2026

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Palladium-Catalyzed Cascade 5-exo-dig Annulation and Amination for Assembly of Amino-Functionalized Trisubstituted
Qiang Tang1,2, Shuwen Kong2, Wangcheng Hu2
1Department of Neurosurgery, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University), The Translational Research Institute for Neurological Disorders and Interdisciplinary Research Center of Neuromedicine and Chemical Biology of Wannan Medical University and Anhui Normal University, Wuhu241001, P. R. China.
Abstract:
A novel route for the preparation of trisubstituted furans with an amino functional group is presented as a palladium-catalyzed cascade 5-exo-dig annulation/amination reaction of α-alkynyl-α,β-enones with N-hydroxybenzamides. The reaction proceeds through a cascade sequence of intramolecular 5-exo-dig annulation, amination, Lossen rearrangement, and decarboxylation, forming two new C-X (X = O, N) bonds in a one-step transformation. This cascade protocol features a wide substrate range and outstanding functional group compatibility and allows an efficient large-scale synthesis and downstream transformations of the target products.
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