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Updated: Oct 16, 2026

Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis
Published on: August 7, 2018
Squeezed to death: Mechanical control of MLKL beyond RIPK3
1Genome Instability, Inflammation and Cell Death Laboratory, Institute of Biochemistry I, Center for Biochemistry, Faculty of Medicine, University of Cologne, 50931 Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany.
Abstract:
Prolonged confinement is a consequence of amoeboid cancer-cell invasion. In this issue of Developmental Cell, Zhang et al.1 show that sustained mechanical stress activates PIEZO1-STAT1-dependent MLKL expression, leading to MLKL-dependent membrane-lytic death in cells without detectable RIPK3 and canonical MLKL phosphorylation, broadening current models of necroptotic competence.
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