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Updated: Oct 16, 2026
An In Vitro Approach to Photodynamic Therapy
Published on: August 17, 2018
Repurposing a polymerization photoinitiator as a self-immolative photodynamic agent for hypoxic cancer therapy
Yueya Zhang1, Yuxuan Tu1, Zhishuo Li1
1State Key Laboratory of Organic Electronics and Information Displays & Jiangsu Key Laboratory of Smart Biomaterials and Theranostic Technology, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing 210023, P. R. China. iambqbao@njupt.edu.cn.
Abstract:
Photodynamic therapy (PDT) is limited by poor tissue penetration, oxygen dependence, and prolonged photosensitivity. A self-immolative near-infrared (NIR) nanoplatform that repurposes a commercial photoinitiator through upconversion-mediated NIR excitation was developed to overcome tumor hypoxia and minimize post-treatment phototoxicity.
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