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Updated: Oct 16, 2026

Intracerebroventricular Injection of Amyloid-β Peptides in Normal Mice to Acutely Induce Alzheimer-like Cognitive Deficits
Published on: March 16, 2016
Peptide vaccination for Alzheimer's disease: Immunological foundations, therapeutic potential, and translational
Haoteng Chen1,2,3,4, Yuanxiang Lin1,2,3,4, DeZhi Kang1,2,3,4
1Department of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China.
Abstract:
In recent years, increasing attention has been directed toward the role of immune responses in the pathogenesis of Alzheimer's disease (AD). The pathological proteins amyloid-β (Aβ) and tau protein are closely associated with immune dysregulation and neuroinflammatory processes during AD progression. Peptide vaccines targeting Aβ and tau have emerged as an active immunotherapeutic strategy designed to induce antigen-specific immune responses against pathological protein aggregates, and several candidates have advanced to early-phase clinical trials. Although preliminary studies have demonstrated acceptable safety profiles and the ability to elicit immune responses, substantial challenges remain in vaccine design, epitope selection, and clinical translation. This review summarizes current progress in peptide vaccine development for AD and discusses their potential applications from an immunological perspective.
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