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Published on: October 22, 2014
Associations between enlarged perivascular spaces and clinical manifestations: a meta-analysis
Rui Zhai1, Yingxiao Ji1, Jihong Liu1
1Department of Neurology, Hebei General Hospital, Shijiazhuang, Hebei Province, China.
Introduction:
Enlarged perivascular spaces (EPVS) are ubiquitous in the elderly and have an insidious onset. Their correlation with clinical symptoms is easily overlooked and controversial. We conducted a meta-analysis to investigate the clinical outcomes associated with EPVS.
Methods:
Relevant studies published up to April 2022 were extracted from PubMed, Embase, Cochrane, OVID, and Web of Science. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to estimate the strength of the associations.
Results:
Of the 6622 articles identified, 32 studies were eligible, including a total of 19,987 people. EPVS were associated with an increased risk of cognitive impairment (OR = 1.60, 95% CI: 1.39-1.81), motor impairment (OR = 2.24, 95% CI: 1.22-3.25), sleep disturbance (OR = 1.81, 95% CI: 1.34-2.28), and depressive symptoms (OR = 1.54, 95% CI: 1.14-1.95), but was not significantly associated with the occurrence of stroke (OR = 0.97, 95% CI: 0.74-1.21). Results of subgroup analysis showed that basal ganglia (BG) EPVS were more strongly associated with cognitive impairment (OR = 2.19, 95% CI: 1.72-2.65) and sleep disturbance (OR = 1.74, 95% CI: 1.20-2.29).
Conclusions:
Our findings suggest that EPVS are associated with cognitive impairment, motor impairment, sleep disturbance, and depressive symptoms. These findings may provide a basis for further investigation of the clinical significance of EPVS.
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