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Updated: Oct 17, 2026
Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
Published on: March 26, 2020
Retinal vasculature changes after 0.125% atropine treatment in children with myopia measured using optical coherence
Yao-Chi Huang1,2, Lan-Hsin Chuang1,2, Ling Yeung1,2
1College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Purpose:
The study assessed the microvascular changes in the retina after the use of 0.125% atropine in children with myopia and the association between retinal microvascular changes and the effects of myopia treatment.
Materials And Methods:
This is a prospective cohort study. Children with myopia aged 5-18 years old were included in the study. Retina microvascular parameters were measured with spectral domain optical coherence tomography (OCT) and OCT angiography devices during the follow-up. The main outcome measurements include vessel density of the superficial vascular plexus (SVP), deep vascular plexus, and axial length (AL).
Results:
A total of 64 eyes of 36 patients were included. A significant decrease in parafoveal vessel density of the SVP was observed in the first 3 months (P = 0.032). The change in parafoveal vessel density of the SVP in the first 3 months correlated negatively with the change in the AL after 1 year (r = -0.430, P = 0.028).
Conclusion:
These results suggest that 0.125% atropine might induce changes in the retina vasculature in children with myopia and that these changes might correlate with myopia progression. Nevertheless, as a pilot study, this result may need to be confirmed in larger studies.
