Related Experiment Video
Updated: Oct 17, 2026

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
Published on: July 21, 2018
LAMB1 accelerates esophageal squamous cell carcinoma by triggering JAK2/STAT3 signaling
Minghao Zhang1, Zhao Liu1, Huilai Lv1
1Department of Thoracic Surgery, The Fourth Hospital of Hebei Medical University, No. 12, Jiankang Road, Shijiazhuang, 050017, Hebei, China.
Background:
Characterized by a high death rate and negative clinical results, esophageal squamous cell carcinoma (ESCC) is a malignant tumor of the digestive tract. Laminin subunit beta 1 (LAMB1), a principal glycoprotein in the extracellular matrix, contributes to the progression of various malignancies. However, the role and regulatory mechanisms of LAMB1 in ESCC are remain unclear. The objective of this study is to examine the expression profile, biological effects, and mechanisms underlying LAMB1 in ESCC.
Methods And Results:
Bioinformatic screening based on TCGA datasets and ECM-related gene sets identified LAMB1 as a prognosis-associated candidate gene. Through quantitative PCR (qPCR), Western blot and immunohistochemistry, we found that LAMB1 expression was increased in ESCC tissues and cell lines. Functional assays showed that LAMB1 overexpression promoted ESCC cell proliferation, migration and invasion, while LAMB1 knockdown suppressed these malignant phenotypes. Mechanistically, LAMB1 activated JAK2/STAT3 signaling by enhancing protein phosphorylation. Both JAK1/2 inhibitor (ruxolitinib) treatment and STAT3 silencing efficiently abrogated LAMB1-driven malignant phenotypes. In vivo xenograft experiments further confirmed that LAMB1 knockdown inhibited tumor growth and inhibited the activation of JAK2/STAT3 pathway.
Conclusions:
LAMB1 facilitates ESCC malignant progression via activating the JAK2/STAT3 pathway. LAMB1 may serve as a promising prognostic biomarker and therapeutic target for ESCC.
Related Concept Videos
The JAK-STAT Signaling Pathway
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
PI3K/mTOR/AKT Signaling Pathway
Abnormal Proliferation
MAPK Signaling Cascades