Related Experiment Video
Updated: Oct 17, 2026
10:37
Single-cell Microfluidic Analysis of Bacillus subtilis
Published on: January 26, 2018
Learning how single cells respond to perturbations
Ekin Deniz Aksu1, Bonnie Berger2
1Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, 14195 Berlin, Germany; Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge, MA 02139, USA.
Molecular Cell
|October 15, 2026
Abstract:
In a recent issue of Cell, Adduri et al.1 introduce State, a machine learning model that generalizes across different cellular contexts and predicts how single-cell transcriptomes respond to genetic or chemical perturbations.
Related Concept Videos
01:23Overview of Cell Signaling
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
01:22Diversity in Cell Signaling Responses
The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity.
Graded and Abrupt Responses
Some signaling systems generate...
Graded and Abrupt Responses
Some signaling systems generate...