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Updated: Oct 17, 2026
Neonatal Mouse Bone Marrow Isolation and Preparation of Bone Marrow-Derived Macrophages
Published on: May 24, 2024
Milking the niche: Microbial control of neonatal hematopoiesis
1Laboratory of Immunophysiology of Pregnancy and Lactation, Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), University of Toulouse, CNRS, INSERM, Toulouse, France.
Abstract:
In this issue of Cell, Howard et al. reveal how the milk glycoprotein osteopontin shapes the neonatal microbiome to regulate hematopoiesis, promoting dendritic cell development and protection from severe respiratory infection. These findings uncover a maternal milk-microbiota pathway linking early-life nutrition to immune development and long-term disease susceptibility.
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