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Programming brain endothelial identity: Transcription factor and genome engineering approaches to improve

Roy W Hwang1, Ying Betty Li2, Richard Marcotte3

  • 1Human Health Therapeutics Research Center, Translational Biosciences, National Research Council of Canada, Ottawa, ON, Canada; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.

Stem Cell Reports
|October 15, 2026
PubMed

Keywords:
CNS drug discoveryblood–brain barrierbrain endothelial cellsendothelial differentiationforward reprogramminggene regulatory networksgenome engineeringiPSC–derived brain endothelial–like cellsinduced pluripotent stem cellstranscription factors

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