Related Experiment Video
Updated: Oct 17, 2026
Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery
Published on: March 27, 2018
Preoperative Naples Prognostic Score and outcomes after isolated coronary artery bypass grafting: a retrospective
Mehmet Sengor1,2,3,4,5, Aykun Hakgor6,7,8,9,10, Ramazan Akal6,7,8,9,10
1Department of Cardiovascular Surgery, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey. sengor_mehmet@hotmail.com.
Background:
Inflammatory and nutritional status may refine risk assessment before coronary artery bypass grafting (CABG). This study evaluated the association between preoperative Naples Prognostic Score (NPS) and early and follow-up outcomes after isolated CABG.
Methods:
This single-center retrospective cohort included adults who underwent isolated CABG between 2020 and 2023. Patients without a recorded preoperative NPS were excluded. The recorded NPS (0-4) was categorized as low (score 0), intermediate (scores 1-2), or high (scores 3-4). Outcomes were institutionally recorded binary event indicators. Logistic regression evaluated associations with 30-day major adverse cardiac and cerebrovascular events (MACCE), follow-up MACCE, and follow-up all-cause death.
Results:
The analytic cohort included 332 patients: 16 low-NPS, 193 intermediate-NPS, and 123 high-NPS patients. Follow-up all-cause death occurred in 25 patients (7.5%) and was more frequent in the high-, intermediate-, and low-NPS groups, respectively (15.4%, 3.1%, and 0.0%; exact P < 0.001). Any follow-up MACCE occurred in 45 patients (13.6%; 18.7%, 11.4%, and 0.0% across the same groups; exact P = 0.050). Thirty-day MACCE occurred in 11 patients (3.3%); its analyses were exploratory. Per 1-point increase in NPS, the adjusted odds ratio for follow-up all-cause death was 1.69 (95% CI 1.00-2.84; P = 0.048) in the clinical model and 2.06 (95% CI 1.25-3.39; P = 0.005) in the EuroSCORE II complete-case model.
Conclusions:
Higher preoperative NPS was associated with greater follow-up all-cause mortality after isolated CABG. Associations with composite MACCE were less consistent after adjustment. NPS may support inflammatory-nutritional risk interpretation alongside established surgical risk assessment, but the findings require confirmation in cohorts with standardized follow-up and time-to-event data.
