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Related Experiment Video

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Gynaecomastia associated with cimetidine.

R W Spence, L R Celestin

    Gut
    |February 1, 1979
    PubMed
    Summary

    Cimetidine treatment for duodenal ulcers can cause gynecomastia (breast enlargement) in men. This side effect resolved after discontinuing the medication, suggesting a link to androgen receptor blockade.

    Area of Science:

    • Endocrinology
    • Gastroenterology
    • Pharmacology

    Background:

    • Cimetidine is a widely used medication for treating duodenal ulcers.
    • Gynecomastia, or male breast enlargement, is a potential side effect of certain medications.

    Purpose of the Study:

    • To investigate the incidence and characteristics of gynecomastia in male patients treated with cimetidine for duodenal ulcers.
    • To explore the potential mechanism behind cimetidine-induced gynecomastia.

    Main Methods:

    • Observational study of 25 male duodenal ulcer patients undergoing cimetidine treatment (1.6 g daily).
    • Monitoring for gynecomastia development, duration, and resolution.
    • Hormonal level measurements (testosterone, estradiol, prolactin) were performed.
    • Histological examination of subareolar tissue in one affected patient.

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    Main Results:

    • Five out of 25 male patients developed unilateral or bilateral gynecomastia after over four months of cimetidine treatment.
    • Gynecomastia regressed rapidly upon cessation of cimetidine therapy.
    • Hormonal profiles, including testosterone and estradiol, remained within normal limits during treatment.
    • Histology confirmed florid gynecomastia in one patient.

    Conclusions:

    • Cimetidine treatment is associated with a significant incidence of gynecomastia in male patients.
    • The mechanism likely involves blockade of androgen-responsive receptors in target tissues.
    • Gynecomastia is reversible upon discontinuation of cimetidine therapy.