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Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling
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Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

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Advanced biomaterial technologies for neural regeneration in central nervous system diseases: mechanisms and

Denale Anniwa1, Zexuan Chen1, Xinglv Chen1

  • 1Mental Health Center, Department of Neurology and Center for Preclinical Safety Evaluation of Drugs, West China Hospital, Sichuan University, Chengdu 610041, China. nizhang@scu.edu.cn.

Nanoscale
|October 16, 2026
PubMed

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...