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Two- and Three-Dimensional Live Cell Imaging of DNA Damage Response Proteins
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TONSL/TONSOKU binding to histone H3.1 is required for DNA repair

Hossein Davarinejad1, Cloé Laflamme2,3, Bianca Dupont1,4

  • 1Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada.

Science Advances
|October 16, 2026
PubMed

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Acetylation
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Histone Modification02:32

Histone Modification

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Nucleosomes, paradoxically, perform two opposite functions simultaneously. On the one hand, their primary aim is to protect the delicate DNA strands from physical damage and help achieve a higher compaction ratio. On the other hand, they must allow polymerase enzymes to access histone-bound DNA during...
The Nucleosome Core Particle02:10

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