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Updated: Oct 18, 2026

Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
Published on: April 3, 2014
Sulphonamide derivatives: A comprehensive review of their diverse therapeutic applications
1Department of Pure and Industrial Chemistry, University of Nigeria, Nsukka, Nigeria; Department of Chemistry, Cross River University of Technology, Calabar, Nigeria.
Abstract:
The sulphonamide functionality (-SO2NR2) remains a highly adaptable privileged functional group that has expanded far beyond its traditional antibacterial role. This review thoroughly explores its ongoing importance in modern drug discovery, focusing on structure-activity relationships (SARs) across various therapeutic fields. This article evaluates recent developments (2008-present) in areas such as antimicrobial, anti-inflammatory, antidiabetic, anti-Alzheimer's, antiviral, and anticonvulsant applications. Critical structural modifications such as substitution at the sulphonamide nitrogen, changes to the aromatic ring, and hybridization with other pharmacophores-are examined for their impact on potency, selectivity, pharmacokinetics, and safety. Overall, these insights highlight the continued relevance of the sulphonamide moiety as a powerful foundation for designing agents aimed at complex disease mechanisms.
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