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[The biliary excretion of azlocillin]
Fortschritte Der Medizin
|March 8, 1979
Summary
Azlocillin achieves high concentrations in human bile, exceeding serum levels significantly. These elevated biliary azlocillin (antibiotic) levels remain above minimum inhibitory concentrations for common biliary pathogens for extended periods.
Area of Science:
- Pharmacology
- Microbiology
- Hepatobiliary Medicine
Context:
- Biliary tract infections (BTIs) are serious conditions often requiring effective antibiotic therapy.
- Understanding antibiotic penetration into bile is crucial for optimizing treatment strategies.
- Azlocillin is a penicillin-class antibiotic with broad-spectrum activity.
Purpose:
- To quantify the excretion of azlocillin into the human biliary tract.
- To compare biliary azlocillin concentrations with concurrent serum levels.
- To assess the duration of effective azlocillin concentrations in bile against common pathogens.
Summary:
- Azlocillin (2g IV) was administered to 8 patients with T-tubes, with serum and bile samples collected for 12 hours.
- Biliary azlocillin levels were approximately 15 times higher than serum levels, peaking at 1137 mg/L.
- Mean bile concentrations remained at 13 mg/L after 12 hours, exceeding MICs for key Gram-negative and Gram-positive bacteria.
Impact:
- Azlocillin demonstrates excellent penetration and sustained high concentrations within the human biliary tract.
- These findings support the potential efficacy of azlocillin in treating biliary tract infections.
- The study provides valuable pharmacokinetic data for azlocillin in the hepatobiliary system.