Related Experiment Video
Updated: Oct 19, 2026

Probiotic Studies in Neonatal Mice Using Gavage
Published on: January 27, 2019
Host-microbiota interaction drives 5-hydroxyindole-3-acetic acid production to promote linear growth in infant mice
Yongmei Yang1, Jing Yang2, Weiyao Zhang1
1School of Life Sciences East China Normal University Shanghai China.
Abstract:
This study discovered that Lactiplantibacillus plantarum Hi188 promoted linear growth in postweaning mice. Transcriptomic analysis, untargeted metabolomics, and in vitro experiments showed that the elevated levels of 5-hydroxyindole-3-acetic acid (5-HIAA) activated the hepatic aryl hydrocarbon receptor (AhR) and subsequently promoted insulin-like growth factor-1 (IGF-1) production via the IRS1/PI3K/Akt pathway. Integrated metagenomics and reverse transcription quantitative polymerase chain reaction (RT-qPCR) analysis of host colonic genes revealed that 5-HIAA was cooperatively produced by the gut microbiota and the host. These findings offered novel perspectives on the therapeutic potential of microbiota-targeted interventions for growth regulation.
Related Concept Videos
Development of Human Microbiota
Microbiota Modulation by Antibiotics
Development of the Oral Microbiota
Introduction to the Human Microbiota
Microbiota of the Stomach and Small Intestine
Microbiota of the Large Intestine

