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Updated: Oct 19, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
Published on: July 28, 2013
Associations of mild behavioral impairment and white matter hyperintensity patterns
Zdenek Linha1, Rafael Dolezal1,2, Matej Seifert1
1Department of Public Health Second Faculty of Medicine Charles University Prague Czech Republic.
Introduction:
It is unclear whether cerebrovascular and white matter changes contribute to mild behavioral impairment (MBI). White matter hyperintensities (WMHs) represent a prominent pathology for research due to association with cognitive decline. We investigated associations between MBI measures and WMH volume and spatial distribution.
Methods:
We analyzed 1273 individuals with normal cognition or mild cognitive impairment. General linear models and voxel-wise analyses were employed to examine WMHs in terms of volume and spatial distribution.
Results:
Greater WMH volume was associated with higher MBI total score and MBI status in participants with normal cognition and mild cognitive impairment. Voxel-wise analysis revealed a significant cluster in the left inferior longitudinal fasciculus associated with higher MBI total score.
Discussion:
Our findings suggest a contribution of WMH volume and spatial distribution to persistent later-life behavioral symptoms. WMHs, especially in the left inferior longitudinal fasciculus, may serve as a neuroimaging marker of behavioral symptoms.
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