Related Experiment Video
Updated: Oct 21, 2026
Clinical Efficacy of Ultrasound-Assisted Scoliosis-Specific Exercise in Mild-Grade Adolescent Idiopathic Scoliosis
Published on: December 2, 2025
Osteopenia in adolescent idiopathic scoliosis
Wenjie Zhong1, Kai Cao2, Fangqian Wu3
1Department of Orthopedic Surgery, Affiliated Rehabilitation Hospital of Nanchang University, Nanchang, China.
Background:
Adolescent idiopathic scoliosis (AIS) is a common type of scoliosis, which occurs in 10 to 18-year-old adolescents and is often accompanied by osteopenia, but the etiology of osteopenia is still unknown. Exploring the etiology may play an important role in fully understanding the pathogenesis of AIS and drawing new treatment ideas.
Purpose:
Understanding the etiology of osteopenia in AIS.
Methods:
This article conducted a comprehensive search across PubMed, Web of Science (WOS), and CNKI for literature concerning osteopenia in adolescent idiopathic scoliosis. The primary search strategy employed "(adolescent idiopathic scoliosis) AND (osteopenia)", supplemented by additional keywords encompassing "bone mineralization disorders", "hormones", "leptin", "calcitonin", "vitamin K", "treatment", etc. The review prioritized recent, high-quality literature.
Results:
This review disclosed the research process of osteopenia in AIS and expounded its possible pathogenesis resulting in osteogenic and bone metabolic abnormalities. Meanwhile, this review summarized some other possible pathogenesis, like gut microbiota, nutritional factors resulting in osteopenia in AIS. Furtherly, the article revealed the relationship between osteopenia and AIS treatment outcome.
Conclusions:
Osteopenia in AIS patients is caused by multiple factors. During the treatment of AIS, it may be necessary to intervene in osteopenia.
More Related Videos
07:12Clinical Efficacy of an Innovative Multidimensional Traction Therapy in Moderate Adolescent Idiopathic Scoliosis
Published on: February 10, 2026
08:08Cell-based Assay Protocol for the Prognostic Prediction of Idiopathic Scoliosis Using Cellular Dielectric Spectroscopy
Published on: October 16, 2013
Related Concept Videos
01:09Changes in the Appendicular Skeleton with Age
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
01:29Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:31Osteoclasts in Bone Remodeling
01:09Spongy Bone
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
01:27Compact Bone
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
01:12General Case of Eccentric Axial Loading
Consider a member subjected to equal and opposite forces that are applied along a line that does not coincide with the member's neutral axis. In unsymmetrical bending,...