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Updated: Oct 21, 2026

Methylated DNA Immunoprecipitation
Published on: January 2, 2009
Epigenetics in development, disease, and therapy: from mechanisms to clinical interventions
Yixuan Ren1,2,3, Lei Yang4, Boyi Fei5,6
1Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
Abstract:
Epigenetics, defined as the regulatory mechanisms that modulate genetic information flow without altering the DNA sequence, plays a crucial role in development, aging, and disease. This review explores the key epigenetic mechanisms-DNA methylation, histone modifications, chromatin remodeling, and non-coding RNAs-and their contributions to cellular differentiation, tissue homeostasis, and disease progression. We focus on their roles in gametogenesis, early development, stem cell reprogramming, and aging, highlighting how epigenetic alterations influence health and disease. The review also discusses emerging therapeutic approaches targeting epigenetic modifications, with potential applications in disease treatment and longevity. Finally, we examine the future of epigenetic research, emphasizing the need for precision therapies and the integration of epigenetic tools in clinical practice.
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