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Updated: Oct 21, 2026
Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
Published on: July 24, 2019
Computerized fine motor assessment in Parkinson's Disease: Task-specific measures provide complementary clinical
Beste Menteşe1, Fatma Nur Savran2, Melike Batum3
1Department of Physiology, Faculty of Medicine, Manisa Celal Bayar University, Manisa, Türkiye. bestementese@gmail.com.
Background:
Fine motor impairment is a common feature of Parkinson's disease (PD) and contributes substantially to functional disability. Although the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS Part III) remains the standard clinical tool for motor evaluation, quantitative computerized assessments may provide complementary task-specific information.
Objectives:
This cross-sectional case-control study compared fine motor performance measured using the Motorische Leistungs-Serie (MLS) between 19 patients with idiopathic PD and 20 healthy controls and examined associations between MLS-derived parameters and clinical motor severity.
Methods:
Motor performance was evaluated using five MLS subtests covering aiming behavior, hand steadiness, precision arm-hand coordination, speed arm-hand, and speed wrist-finger tasks.
Results:
After adjustment for age, sex, and educational level, patients with PD showed significantly poorer overall fine motor performance, as reflected by the Composite Motor Performance Score, together with significant impairments in selected task-specific measures of aiming performance and visuomotor tracking. Several MLS-derived parameters, particularly aiming duration and hand steadiness, were significantly associated with MDS-UPDRS Part III scores.
Conclusion:
These findings suggest that MLS-derived task-specific measures provide objective quantitative information that complements conventional clinical motor assessment in Parkinson's disease. Analysis of individual task-specific parameters may provide complementary clinically relevant information beyond a single global composite score. However, larger prospective studies are required to determine the clinical utility of task-specific computerized fine motor assessment for monitoring disease progression and treatment response.
