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Updated: Oct 22, 2026
08:55
Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS-PAGE with a Phosphate-binding Tag
Published on: December 14, 2017
Swollen lysosomes grab Rabs for a CASM-free route to LRRK2 activation
1Stanford University School of Medicine , Stanford, CA, USA.
The Journal of Cell Biology
|October 20, 2026
Abstract:
Multiple lysosomal stresses activate Parkinson's-linked LRRK2 kinase, and these involve the so-called "CASM" pathway to help recruit LRRK2 to lysosome surfaces. Clegg et al. (https://doi.org/10.1083/jcb.202511137) show that LRRK2, activated upon lysosome swelling caused by PIKfyve inhibition, instead relies solely on Rab GTPase binding for lysosome localization and activation.
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