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Updated: Oct 22, 2026

Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction
Published on: September 14, 2018
The next click in antibody drug conjugate development
Avantika Gupta1, Sarat Chandarlapaty2
1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Abstract:
The clinical success of antibody drug conjugates has been shaped by the promise of delivering cytotoxic payloads precisely to tumors while minimizing systemic exposure. Simó and colleagues aim to improve on conventional ADC delivery by decoupling tumor localization from payload delivery to enhance pharmacokinetics and addressing antigen heterogeneity by enabling dual targeting.
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