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Updated: Oct 22, 2026
Dynamic Assessments of Coronary Flow Reserve after Myocardial Ischemia Reperfusion in Mice
Published on: August 25, 2023
Reversible wall motion abnormalities do not predict long-term mortality if coronary flow reserve is accounted for: A
Nicola Gaibazzi1, Giampaolo Niccoli1, Daniele Sartorio1
1Cardiology Department, Parma University Hospital, Parma, Italy.
Background:
Stress echocardiography (SE) is widely used to detect myocardial ischaemia in the scenario of chronic coronary syndromes (CCS). Despite that, the prognostic value of SE has been rarely assessed. We aim to establish whether the presence of reversible wall motion abnormalities (RWMA), remains independently associated with long-term mortality when considering myocardial perfusion (MP) and Doppler coronary flow velocity reserve in the left anterior descending artery (CFVR-LAD).
Method:
1002 subjects who underwent Dipyridamole contrast SE, for suspected CCS, between 2007 and 2012 at the Parma University Hospital were enrolled. The endpoint is all-cause mortality. The probability of survival was calculated using the Kaplan-Meier method and event-rate curves were compared using the log-rank test.
Results:
There were 376 deaths (37.5%) during a median follow-up of 13.8 years. Mean age was 66 ± 11 years, females represented 38%, 32% had known CCS. SE results showed RWMA in 17.5%, reversible MP abnormalities in 26.2%, and reduced CFVR-LAD in 42% of the study population. Revascularization within 3 months of the SE was performed in 185 subjects (18.5%). In multivariate Cox proportional hazard analysis, among the SE variables, only CFVR-LAD<2 remained associated with mortality (HR 2.44, 95% CI 1.94-3.5, p < 0.0001).
Conclusion:
In the setting of CCS patients, CFVR-LAD is the only SE variable maintaining independent association with long-term mortality.
