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Updated: Oct 22, 2026
Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
Published on: November 27, 2019
EXPRESS: Letter to the Editor Regarding "Much ado about eating: Intermittent fasting and post-stroke neuroprotection"
Guilherme Bezerra Carneiro1, Carolina Moreno Pace2, Eberval Gadelha Figueiredo3
1Division of Medicine, University of São Paulo, Av. Dr. Arnaldo, 455, Cerqueira César, São Paulo, SP 01246-903, Brazil.
Abstract:
Vemuganti and colleagues highlight intermittent fasting (IF)'s neuroprotective potential post-stroke via autophagy and mitochondrial biogenesis. However, clinical translation faces hurdles in metabolically vulnerable patients. This letter critiques IF's bedside applicability, emphasizing post-stroke catabolic stress, dysphagia (~50% cases), sarcopenia risk, and cardiovascular concerns. Recent evidence links short eating windows to higher mortality, countering IF benefits. The obesity paradox suggests nutritional reserves aid survival. Strategies: protein-prioritized planning, dysphagia screening, dietitian monitoring, and supplements. Until RCTs confirm safety/efficacy, prioritize nutritional adequacy. Preclinical insights warrant study.Keywords: dysphagia, intermittent fasting, neuroprotection, obesity paradox, sarcopenia.
