Related Experiment Video
Updated: Oct 24, 2026

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
Published on: December 7, 2021
Variational physics-informed ansatz for reconstructing hidden interaction networks from steady states
1College of Future Information Technology, Fudan University, Shanghai 200438, China.
Abstract:
Inferring interaction structure from steady-state observations is a central inverse problem when transient trajectories are unavailable. Here, we formulate this problem as simultaneous compatibility of a single interaction operator with equilibrium constraints generated by heterogeneous perturbations. We introduce a variational physics-informed ansatz that represents the unknown operator as a trainable object and minimizes the resulting steady-state residuals across experiments. In the affine-interaction setting, the stacked equilibrium equations yield explicit finite-sample identifiability conditions: unique recovery is controlled by the rank of the compatibility matrix after elimination of experiment-wise gauge freedom. Synthetic benchmarks on pairwise, directed, weighted, empirical-topology, and selected higher-order systems illustrate this identifiability picture and show how additional heterogeneous steady states improve structural discrimination under the stated assumptions. The results clarify a concrete steady-state reconstruction regime in which equilibrium observations alone can determine hidden interaction operators when the governing dynamics are known and node-level equilibria are fully observed.
Related Concept Videos
Reaction Mechanisms: The Steady-State Approximation
First Law: Particles in Two-dimensional Equilibrium
Newton's first law tells us about the...
Protein Networks
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Equilibrium Conditions for a Particle
To understand the concept of equilibrium, let us first consider the forces acting on an object. When different forces act on an object, they can...
Linear Approximation in Time Domain
For a simple pendulum with a mass evenly distributed along its length and the center of mass located at half the pendulum's length, the...
First Law: Particles in One-dimensional Equilibrium
