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The Potential Utility of Model-Informed Precision Dosing in Children
Shane J Cross1, John Carl Panetta1
1Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Abstract:
Model-informed precision dosing (MIPD) is an emerging strategy to optimize drug therapy in children by addressing variability in drug exposure. By integrating population pharmacokinetic (PK) models with patient-specific covariates and serum drug concentration data, MIPD provides individualized dosing recommendations. Evidence supports improved PK target attainment for several anticancer and antimicrobial agents. However, broad implementation is hindered by resource limitations and challenges in generating robust clinical outcomes data in small pediatric populations. Advances in modeling, simulation, and electronic health record functionality are enhancing feasibility and may facilitate broader adoption of MIPD in pediatric clinical practice.
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