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Updated: Oct 24, 2026
08:39
Tracking Single Proteins in Lipid Bilayers Using Fluorescence Microscopy
Published on: December 12, 2025
Lipid droplet targeting at single-molecule resolution
1Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland; Molecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Trends in Cell Biology
|October 22, 2026
Abstract:
Lipid droplet proteins can move from the endoplasmic reticulum to droplets through persistent membrane connections. A new single-molecule study reveals that accumulation is not only about access: protein sequence features tune residence on the droplet surface, revealing how confined mobility can lead to accumulation on the organelle (Mizrak et al.).
