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Adenovirus endocarditis in mice
Science (New York, N.Y.)
|July 7, 1967
Summary
Murine adenovirus caused viral endocarditis in newborn mice. The virus was detected in heart tissue and within heart valve cells, confirming its role in the infection.
Area of Science:
- Virology
- Cardiovascular Pathology
- Infectious Diseases
Background:
- Viral infections can affect various organ systems, including the cardiovascular system.
- Endocarditis, inflammation of the heart lining, can have diverse etiologies.
Purpose of the Study:
- To investigate the potential of murine adenovirus to induce viral endocarditis in a neonatal mouse model.
- To characterize the pathological and virological features of adenovirus-induced endocarditis.
Main Methods:
- Neonatal mice were inoculated intraperitoneally with murine adenovirus.
- Heart tissues were examined for pathological changes, viral inclusions, and virus titers.
- Electron microscopy was used to visualize viral particles within cardiac cells.
Main Results:
- Viral endocarditis developed in 24% of inoculated mice 6-8 days post-infection.
- Characteristic adenovirus intranuclear inclusions were observed in heart valve lesions.
- High virus titers were recovered from heart tissue, and adenovirions were visualized in endothelial cells and fibroblasts.
Conclusions:
- Murine adenovirus can cause viral endocarditis in newborn mice.
- The findings demonstrate the direct involvement of adenovirus in cardiac tissue, specifically heart valves.