Related Experiment Video
Updated: Oct 24, 2026
A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers
Published on: January 5, 2024
Effects of local vibration therapy and gabapentin on restless legs syndrome symptoms: a randomized controlled trial
Gholamreza Raissi1, Bijan Forogh2, Hamid Ansari3
1Neuromusculoskeletal Research Center, Department of Physical Medicine and Rehabilitation, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Objective:
This study aimed to evaluate the effect of LV in combination with gabapentin, a first-line medication for RLS, on the treatment of patients with the condition.
Results:
In total, 36 participants (18 in each group) participated in this study, with 10 (55%) being male within each group. The mean age of participants was 45 years (SD = 10.6) in the LV group and 49.1 (SD = 8.3) in the gabapentin group. In both the LV and gabapentin groups, IRLSSG scores decreased significantly after the intervention compared with baseline (p < 0.001). However, scores increased at the one-month follow-up, although they remained lower than pre-intervention values (p < 0.001). A similar pattern was observed for the PSQI scores (p < 0.001). There were no significant differences between groups at any timepoint (p > 0.05).
Trial Registration:
The study protocol was registered at the Iranian Registry of Clinical Trials on August 30th, 2023 (code IRCT20190306042945N4).
