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Characterization of Diabetic Retinopathy in Trimesters of Pregnancy
Kanika Seth1, Neil A Rana2, Jason M Singer2
1Center for Ophthalmic Bioinformatics, Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA.
Purpose:
To evaluate the relationship between trimester of pregnancy and stage of diabetic retinopathy (DR) in a cohort of women with diabetes.
Methods:
In this single-center, retrospective cohort study, data were collected from adult women with diabetes who experienced a pregnancy at 5 timepoints: prepregnancy, each trimester, and postpregnancy. Progression, manifestation, and improvement of DR were tracked via logistic regression.
Results:
A total of 158 patients were analyzed. Among them, 13 (8.2%) showed progression to worse stage of DR during pregnancy, of whom 6.9%, 5.0%, and 14.3% had progression within the prepregnancy/first trimester, second trimester, and third trimester brackets, respectively, and 10.0% progressed postpregnancy; differences between the trimesters regarding incidence of DR progression were nonsignificant (P = .42). Of patients with no retinopathy at baseline, 4.62%, 7.69%, and 5.88% developed DR in each of the 3 trimesters, respectively, and 6.45% developed DR postpregnancy; differences in rates of DR manifestation were nonsignificant (P = .97).
Conclusions:
Pregnancy stage was not associated with risk of DR manifestation or progression in this cohort.
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