HuRInterDB: A Database Exploring the Landscape of lncRNA-Protein Interactions

Long noncoding RNAs (lncRNAs) possess diverse biological functions and play key regulatory roles in biological processes by interacting with other biomolecules, such as proteins, RNAs, and the genome. High-throughput RNA-interaction experiments have generated large volumes of lncRNA-protein interaction records. The fragmented deposition of these records across disparate public databases complicates unified retrieval and integrative analysis. Here, we present HuRInterDB (Human lncRNA-Protein Interaction Database), a comprehensive and standardized database that focuses on human lncRNA-protein interactions. HuRInterDB is a user-friendly database designed to provide an integrated resource of lncRNA-protein interaction data from 621 high-throughput datasets (encompassing 2,440,594 lncRNA-protein interactions derived from 36,184 lncRNAs and 14,888 proteins) and to support functional research on lncRNA. The web interface supports interactive searching and visualization of lncRNA-protein associations. This curated resource streamlines integrative analysis of lncRNA-protein interactions and provides a standardized foundation for future computational and experimental studies. Distinctive features include an integrated analysis module that enables interactive visualization of protein-protein interaction networks, functional word clouds, and Gene Ontology enrichment bubble plots for any queried lncRNA, as well as download functionality. HuRInterDB is freely accessible at https://nwu26-hurinterdb.share.connect.posit.cloud/, with semiannual updates and complete data downloads.