Related Experiment Video
Updated: Oct 25, 2026

Intraoperative Gastroscopy for Tumor Localization in Laparoscopic Surgery for Gastric Adenocarcinoma
Published on: August 9, 2016
Case of Appendiceal Goblet Cell Adenocarcinoma With Gastric Metastasis
A Gautam1, M Jafferjee1, K Nimmagadda1
1Baylor Scott & White All Saints Medical Center, Fort Worth, TX.
Abstract:
Goblet cell adenocarcinoma (GCA) is a rare appendiceal neoplasm that typically metastasizes to the peritoneum and pelvic organs, with no reported gastric involvement. We report a 72-year-old man with multiple comorbidities presenting with recurrent small bowel obstruction. Imaging revealed a cecal and a gastric mass; colonoscopy confirmed poorly differentiated right-sided adenocarcinoma. Surgical resection with intraoperative biopsies identified high-grade appendiceal GCA infiltrating the cecum, mesentery, and gastric wall. Immunohistochemical staining showed cytokeratin 7 negativity and cytokeratin 20 positivity, suggesting an appendiceal origin. Endoscopic ultrasound-guided fine-needle aspiration of the gastric lesion confirmed gastric metastasis, demonstrating identical morphology and immunoprofile, thus expanding the metastatic spectrum of GCA.
Related Concept Videos
Appendicitis
Appendicitis-I: Introduction
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
Metastasis
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...