Related Experiment Video
Updated: Oct 25, 2026

A Simple and Efficient Protocol for the Catalytic Insertion Polymerization of Functional Norbornenes
Published on: February 27, 2017
Chromonyl-norbornyl-palladacycle intermediate: progress and synthetic utility in chromone functionalization
Mi-Zhuan Li1, Hui-Min Li2,3, Jian-Shu Wang2
1School of Public Health, Zunyi Medical University, Zunyi 563006, P. R. China.
Abstract:
Chromone is a privileged oxygen-containing heterocyclic scaffold widely distributed in natural products and bioactive molecules. Chromone derivatives exhibit diverse biological activities, making this structural motif highly valuable for drug discovery and functional molecule development. The chromonyl-norbornyl-palladacycle (CNP) intermediate, a key species derived from norbornene-mediated palladium-catalyzed C-H activation, has emerged as a powerful platform for the modular construction of functionalized chromone derivatives. Herein, we provide a systematic overview of CNP-mediated synthetic approaches to chromone derivatives, classify these methods by reaction type and mechanistic features, and discuss remaining challenges and future perspectives, to inspire further development of chromone synthetic methodologies.
Related Concept Videos
Cycloaddition Reactions: Overview
Halogenation of Alkenes
Consider the bromination of cyclopentene. Molecular bromine is polarized in the proximity of the π electrons of cyclopentene. An electrophilic bromine atom adds across the double bond, forming a cyclic bromonium ion intermediate.
Preparation of Alkynes: Alkylation Reaction
Alkylation of terminal alkynes with primary alkyl halides in the presence of a strong base like sodium amide is one of the common methods for the synthesis of longer carbon-chain alkynes. For example, treatment of 1-propyne with sodium amide followed by reaction with ethyl bromide yields 2-pentyne.
Preparation of Alkynes: Dehydrohalogenation
Alkynes can be prepared by dehydrohalogenation of vicinal or geminal dihalides in the presence of a strong base like sodium amide in liquid ammonia. The reaction proceeds with the loss of two equivalents of hydrogen halide (HX) via two successive E2 elimination reactions.
Cycloaddition Reactions: MO Requirements for Photochemical Activation
Olefin Metathesis Polymerization: Ring-Opening Metathesis Polymerization (ROMP)
![Solid-phase Synthesis of [4.4] Spirocyclic Oximes](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F58508.jpg&w=3840&q=50)
