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Updated: Oct 25, 2026

Syntheses, Crystallization, and Spectroscopic Characterization of 3,5-Lutidine N-Oxide Dehydrate
Published on: April 24, 2018
Single-Atom Nickel-Catalyzed C-H Amidation of Pyridine and Quinoline N-Oxides
Yijie Jiang1, Yanze Lu1, Haijing Li2
1Key Laboratory of Material Chemistry for Energy Conversion and Storage, Ministry of Education, Hubei Key Laboratory of Material Chemistry and Service Failure, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan430074, China.
Abstract:
A single-atom nickel catalyst (Ni-N-C-700) was developed for the efficient direct amidation of quinoline N-oxides with dioxazolones, providing a broad range of 2-acetamidoquinoline N-oxide derivatives. Two one-pot synthetic routes starting from commercially available quinoline were also designed, enabling the flexible preparation of both 2-acetamidoquinoline N-oxides and the pharmaceutically relevant 2-aminoquinoline scaffolds. The single-atom nickel catalyst showed good stability, recyclability, and operational simplicity, while EXAFS analysis revealed a well-defined Ni-N4 coordination environment. A hot filtration experiment confirmed the heterogeneous nature of the catalytic system. This work provides a practical approach to the 2-acetamidoquinoline N-oxide and further illustrates the utility of heterogeneous nickel catalysis in C-H functionalization reactions.
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