Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The Nb rat: prostatic adenocarcinoma model.

J R Drago, R M Ikeda, R E Maurer

    Investigative Urology
    |March 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Prognostic significance of DNA ploidy in Ta/Tl bladder cancer: A southwest oncology group study.

    Urologic oncology·2011
    Same author

    A cancer prevention and detection clinic.

    Journal of the American Medical Association·2010
    Same author

    Determination of the molecular orientation of poly(propylene terephthalate) fibers using polarized Raman spectroscopy: a comparison of methods.

    Applied spectroscopy·2004
    Same author

    Rotational invariants for polarized Raman spectroscopy.

    Applied spectroscopy·2003
    Same author

    Studying "exposure" to firearms: household ownership v access.

    Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention·2003
    Same author

    Prevalence of youth access to alcohol or a gun in the home.

    Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention·2002

    The Noble rat prostatic adenocarcinoma is a valuable animal model for studying human prostate cancer. It accurately mimics human disease characteristics and aids in evaluating new chemotherapy drugs.

    Area of Science:

    • Oncology
    • Animal Models
    • Prostate Cancer Research

    Background:

    • The Noble rat prostatic adenocarcinoma serves as a critical animal model for human prostate carcinoma.
    • It exhibits histological, biochemical (acid phosphatase production), and consistent tumor growth similarities to human prostate cancer.
    • This model is characterized by hormonal dependency and metastatic potential.

    Purpose of the Study:

    • To highlight the utility of the Noble rat prostatic adenocarcinoma as an animal model for prostate cancer research.
    • To emphasize its value in evaluating cytotoxic chemotherapeutic agents.
    • To encourage greater attention from the urologic community towards this model for therapeutic development.

    Main Methods:

    • Histological examination of tumor tissues.

    Related Experiment Videos

  • Biochemical analysis of acid phosphatase levels.
  • Monitoring of tumor growth rates and metastatic progression.
  • Assessment of hormonal dependency.

    • Main Results:

    • The Noble rat prostatic adenocarcinoma accurately replicates human prostate cancer histology.
    • Biochemical markers, such as acid phosphatase, are consistent with human disease.
    • Tumor growth is relatively constant, and the model exhibits hormonal dependency and metastasis.

    Conclusions:

    • The Noble rat prostatic adenocarcinoma is a well-established and reliable animal model for human prostate cancer.
    • Its comprehensive mimicry of human disease makes it ideal for preclinical studies.
    • This model offers a promising platform for the evaluation of novel cytotoxic chemotherapeutic agents in urologic oncology.