Cloud based solid state NMR automated processing (SNAP): A digital solution to enable efficient and robust data...

Solid state NMR (ssNMR) enables molecular level structural interrogation across drug discovery and development, and specifically, the stability assessment of chemical and biological therapeutics. However, routine application in pharmaceutical settings is constrained by inherently low sensitivity, complex data analysis, and fragmented workflows that rely on multiple proprietary software packages, limiting accessibility, throughput, and reproducibility. Herein, we developed Solid-state NMR Automated Processing (SNAP), a cloud-based software platform with a web interface designed to streamline ssNMR data handling. SNAP imports raw NMR free induction decay (FID) signals, automates preprocessing, performs spectral fitting, and enables graphical spectral analysis. The platform consolidates discrete file transformation steps into a single, automated workflow and supports standardized export to reporting documentation. We demonstrated across representative ssNMR datasets that SNAP reduced manual steps, simplified multistage processing, and improved the consistency of spectral analysis and reporting relative to conventional approaches that require multiple software tools. The consolidated workflow increased efficiency and supported reproducible quantification. By integrating acquisition-to-reporting tasks into a single, automated pipeline, SNAP enhances throughput, robustness, and confidence in ssNMR data processing and quantification. This digital solution is designed to improve the accessibility and efficiency of ssNMR in pharmaceutical development.